Roma will miss Zlatano Ibrahimovic and Andrea Pignata for the next two home games against Juventus and Napoli, according to coach Marco Asensio.
The pair had been the only players who could play together for the first time in the new season as Roma took advantage of the absence of the injured Ibrahimovic to score their first league goal.
Pirlo will miss the match with a hamstring injury.
Pignata will be sidelined for three weeks with an ankle injury, while Bonucci will be unavailable for the rest of the season.
